White Matter Characteristics of Idiopathic Normal Pressure Hydrocephalus: A Diffusion Tensor Tract-Based Spatial Statistic Study

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White Matter Characteristics of Idiopathic Normal Pressure Hydrocephalus: A Diffusion Tensor Tract-Based Spatial Statistic Study

Using magnetic resonance-diffusion tensor imaging (DTI), we examined white matter changes within the brains of patients diagnosed with idiopathic normal pressure hydrocephalus (INPH). We analyzed data for 24 INPH patients who were presented with typical clinical symptoms (gait disturbance, dementia, and/or urinary incontinence) and Evans index > 0.3, and compared these with the control data fro...

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White matter alteration in idiopathic normal pressure hydrocephalus: tract-based spatial statistics study.

BACKGROUND AND PURPOSE White matter alteration in iNPH has not been well-investigated. TBSS is a voxelwise statistical analysis developed for DTI data. We aimed to elucidate the cerebral white matter alteration in patients with iNPH by using DTI and to test the accuracy of TBSS analysis. MATERIALS AND METHODS DTI data were obtained from 20 patients with iNPH and 20 age- and sex-matched contro...

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Idiopathic Normal Pressure Hydrocephalus

Idiopathic normal pressure hydrocephalus (iNPH) is a potentially reversible neurodegenerative disease commonly characterized by a triad of dementia, gait, and urinary disturbance. Advancements in diagnosis and treatment have aided in properly identifying and improving symptoms in patients. However, a large proportion of iNPH patients remain either undiagnosed or misdiagnosed. Using PubMed searc...

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Differential diagnosis of idiopathic normal pressure hydrocephalus from other dementias using diffusion tensor imaging.

BACKGROUND AND PURPOSE Because DTI can provide good markers of white matter pathology, it could be useful in differentiating white matter changes of INPH from those of other dementias. The aim of this study was, by using DTI, to compare the characteristic white matter changes in INPH with those in AD, subcortical vascular dementia, and healthy control subjects. MATERIALS AND METHODS Sixteen p...

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ژورنال

عنوان ژورنال: Neurologia medico-chirurgica

سال: 2013

ISSN: 0470-8105,1349-8029

DOI: 10.2176/nmc.oa2012-0307